Syphilis of the nervous system
Syphilitic lesions of the nervous system manifested a variety of pathological changes, and numerous clinical symptom. Morphology of tissue reaction characterized by a certain reactive state of the organism and its individual tissues. The nature of the tissue reaction in different periods of the disease varies. In the initial period of syphilis of the nervous system inflammation of the soft meninges and blood vessels characterized by a predominance of exudative component and the speed of flow of the inflammatory process, ie. E. Characteristic of hyperergic inflammation.
- Usually mentioned changes coincide with syphilis of second period, when both are observed generalized skin lesions, mucous membranes, lymph nodes and other organs. At this stage there is increased sensitivity to pathogen infection and simultaneously develops lowering its resistance, which leads to a generalization of the process.
- In the future, the nature of the tissue response varies – exudative component to join the phenomenon of productive inflammation in the form of a diffuse infiltration of the gummy, education solitary Gunma gummy vascular wall, usually leading to the obliteration of the arteries and veins.
- Factors predisposing to the emergence of the nervous system lesions, include such as alcoholism, physical injury of the nervous system, its over-voltage due to mental fatigue or long-term severe mental experiences, leading to the development of a neurotic state.
- The general weakening of the body due to chronic wasting disease (tuberculosis, brucellosis, diseases of internal organs, endocrine and nervous system) leads to a decrease in its resistance and contributes to the emergence of specific lesions of the nervous system. This is facilitated by certain environmental conditions: poor nutrition, poor working conditions, living conditions, occupational intoxication. Elderly also are points favoring the development of syphilitic lesions of the nervous system.
Is crucial to the treatment of these patients in the past: a full and timely manner specific therapy is better, although incomplete, guarantee against lesions of the nervous system. Heavy syphilitic lesions of the nervous system develops normally from untreated or insufficiently treated patients.
There are two clinical forms of syphilis of the nervous system:
- early, or mesenchymal or meningovascular
- late, or parenchymal, syphilis of the nervous system.
- A clinical form of syphilis is characterized by a different degree of participation in the tissue reaction mesenchymal tissue. In early syphilis of the nervous system to the forefront mesenchymal reaction parenchymal elements involved in the process a second time; and in late syphilis of the nervous system dominated by degenerative changes in parenchymal cells, mesenchymal reaction recedes into the background.
It should, however, bear in mind that all the symptom of early and late syphilis linked transitional forms representing various combinations of early and late syphilis of the nervous system.
Syphilitic lesions of the nervous system are set out in detail in the manuals of neuropathology.